Article
Phosphatidylserine Benefits: What Small Trials and the FDA Claim Say
Phosphatidylserine benefits are slight in the research. Small trials showed minor cognitive gains that were not large enough to matter clinically, and the FDA allowed only qualified claims, noting very little evidence. Phosphatidylserine is one of six names listed for MemoPryl.
Prepared by the MemoPryl label deskUpdated · 4 min read
Trials01
What are the phosphatidylserine benefits seen in studies?
Phosphatidylserine benefits in studies are slight cognitive gains that were not clinically relevant. Most trials lasted under six months and were small (ADDF, phosphatidylserine).
A 2022 meta-analysis hinted at a possible memory gain, but the trials are hard to compare. Typical research intakes ran from 80 to 500 mg a day, which is not an amount in MemoPryl.
FDA claim02
What did the FDA say about phosphatidylserine claims?
The FDA allowed only qualified claims for phosphatidylserine and found very little evidence behind them. That is not approval of any product (FDA, phosphatidylserine claim).
The claim wording comes from a trade report, so treat the exact current text as unverified. The FDA does not approve supplements before sale (FDA, using supplements).
Six names03
Where does phosphatidylserine sit among the six MemoPryl names?
Phosphatidylserine is first on the list of six names. Its amount in the capsule is not published.
| Label line | Group | Per serving | % DV | Amount used in research | Evidence |
|---|---|---|---|---|---|
| Phosphatidylserine | Nutrients and amino acids | Not published | Not known | Typical supplement intake is cited as 80 to 500 mg a day; trials were small and mostly under 6 months (FDA, phosphatidylserine claim) (ADDF, phosphatidylserine) | Limited and preliminary; the FDA allowed only qualified claims |
| Ginkgo biloba leaf | Herbal extracts | Not published | Not known | 240 mg a day of a specific dry extract in the European monograph for mild dementia (NCCIH, Ginkgo) (Cochrane, Ginkgo (PEARLS)) (EMA/HMPC, Ginkgo monograph) (MSK, Ginkgo) | Inconsistent; large trials found no prevention of dementia |
| N-Acetyl L-Carnitine HCl | Nutrients and amino acids | Not published | Not known | 1,000 to 3,000 mg a day in dementia trials (Cochrane, acetyl-L-carnitine) (NIH ODS, Carnitine) | No evidence of benefit in the Cochrane review of dementia trials |
| St. John's wort | Herbal extracts | Not published | Not known | Depression trials used standardized extracts for 4 to 12 weeks; not studied for memory (NCCIH, St. John's wort) (NCCIH, St. John's wort in depth) (Cochrane, St. John's wort) (NCCIH, herb-drug interactions) | Researched for mild to moderate depression rather than memory |
| Brahmi / Bacopa monnieri | Herbal extracts | Not published | Not known | 300 to 450 mg a day of extract for 12 weeks in small trials (Pase 2012, Bacopa review) (Bacopa meta-analysis 2014) (LiverTox, Bacopa) (Merck Manual, Bacopa) | Small, early trials; modest and inconsistent memory results |
| L-glutamine | Nutrients and amino acids | Not published | Not known | No studied dose for memory (Ogden 2020, L-glutamine tolerance) | No evidence for memory in the sources found |
Next step04
Should you ask about it?
Yes, ask a pharmacist, since it may lower blood pressure or raise bleeding risk. Keep taking prescribed medicine.
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FAQ05
Phosphatidylserine questions
Does phosphatidylserine work for memory in older adults?
Evidence is thin. Small trials showed slight gains that were not large enough to be clinically relevant, and larger confirmation is missing (ADDF, phosphatidylserine). See a doctor about memory worries.
How long do phosphatidylserine trials last?
Most lasted under six months (ADDF, phosphatidylserine). That tells you little about long-term use. No trial of the MemoPryl capsule itself was found, so its effects over time are unknown.
Is the FDA phosphatidylserine claim proof it works?
No. The claim was qualified, and the FDA noted very little evidence behind it (FDA, phosphatidylserine claim). A qualified claim is a limited statement, not a seal of approval.
Who wrote this06
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