Article
Phosphatidylserine Side Effects: Safety Notes From Trials and Reviews
Phosphatidylserine side effects were not serious in small trials, but those trials were short. Supplements may lower blood pressure, raise weight or raise bleeding risk. Phosphatidylserine is one of six names listed for MemoPryl, so ask a pharmacist before use.
Prepared by the MemoPryl label deskUpdated · 3 min read

Effects01
What are the phosphatidylserine side effects?
Phosphatidylserine side effects were not serious in small trials. Most trials lasted under six months, so long-term safety is less clear (ADDF, phosphatidylserine).
Possible issues named by one review are lower blood pressure, weight gain and higher bleeding risk (ADDF, phosphatidylserine).
| Caution | Who should ask first |
|---|---|
| Lower blood pressure | People on blood pressure medicine |
| Bleeding risk | People on blood thinners or facing surgery |
| Weight gain | Anyone watching weight |
Source02
Does the source of phosphatidylserine matter?
Yes, older products from cow brain were replaced by plant or marine sources over prion concerns. The source of a capsule is a fair question for the seller (ADDF, phosphatidylserine).
No supplement facts panel was found for MemoPryl, so its source and amount are not published. Ask the order desk.
When to stop03
When is it time to stop and call a doctor?
Stop and call a doctor or pharmacist for unusual bleeding, dizziness or any new symptom you cannot explain. Call 911 for sudden confusion or weakness. Write down the date and the time of your last capsule.
- Daily life disruptedForgetting recently learned things, repeating questions, relying on notes for everything
- Lost in familiar placesGetting lost in your own neighborhood or on a usual route
- Trouble with usual tasksCooking, paying bills or using a phone becomes hard
- Words and namesUsing odd words for familiar things, or forgetting a close relative's name
- Mood or personality changeWithdrawal, suspicion, new anxiety or poor judgment
See a doctorAny of these signs, or memory trouble that is getting worse, is a reason to see a doctor. Early diagnosis helps with treatment and planning. A supplement should not delay it.
Go nowSudden confusion, trouble speaking, weakness on one side of the body, or a severe sudden headache can be a stroke or another emergency. Call 911 or go to an emergency room.
Warning signs from the CDC and the Alzheimer's Association (CDC, dementia signs) (Alzheimer's Assoc., 10 signs).
Next step04
How can you lower the risk?
Show the bottle and your medicine list to a pharmacist. Keep taking prescribed medicine exactly as directed.
The price shows at checkout if you look.
FAQ05
Phosphatidylserine safety questions
Can phosphatidylserine affect blood pressure?
It may lower it, according to one review (ADDF, phosphatidylserine). If you take blood pressure medicine, keep taking it and ask your doctor or pharmacist before adding a supplement that could stack the effect.
Is phosphatidylserine risky before surgery?
It may raise bleeding risk (ADDF, phosphatidylserine), so tell your surgical team about every supplement. They will decide on timing. Do not stop a prescribed medicine by yourself.
Is phosphatidylserine safe with blood thinners?
Ask first. A review notes it may increase bleeding risk (ADDF, phosphatidylserine), which could add to a blood thinner. Keep taking your prescription and ask the prescriber or pharmacist.
Who wrote this06
Written and reviewed by
Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.
Last updated . Find our editorial standards and how we check reviews. This website is run by a U.S. order-link partner, not by the maker of MemoPryl. This site earns a commission when you buy through our order links.
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